Yes. If you are attempting to detox from stimulants like cocaine, you can usually expect to have around 72 hours of discomfort, but after that, the physical process will ease up significantly. Opioid drugs such as heroin tend to present a lot more difficulty. The physical process of detox generally takes longer than in the case of other drugs, and attempting an unsupervised detox can result in severe health consequences. For this reason, it is always best to seek professional help before beginning the detox process.